Author(s): Sunita N Surse Sushil D Patil Kunal R Deshmukh Sanjay J Kshirsagar

Email(s): sunitasurse@gmail.com , sushilpharma@rediffmail.com

DOI: 10.5958/2231-5675.2019.00039.5   

Address: Sunita N Surse* Sushil D Patil* Kunal R Deshmukh* Sanjay J Kshirsagar
Pharmaceutical Quality Assurance Technique, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgoan, Nashik, Savitribai Phule Pune University.
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2019


ABSTRACT:
A Simple, Sensitive, Precise and Specific high performance liquid chromatography method was developed and validated for the determination of tioconazole drug. The separation was carried out by using a mobile phase consisting of methanol: phosphate buffer (pH3) in ratio of 95:05. The column used was cosmosil C18 ( 250 mmx 4.6 ID ) Flow rate of 0.9 ml/min. using UV detection at 220 nm . The retention time of tioconazole was found to be 4.67 min. resp. A forced degradation study of tioconazole in its API form was conducted under the condition of hydrolysis, oxidation, thermal and photolysis. The methods were validated by following the Analytical performance parameters suggested by the International Conference on Hormonaization (ICH).


Cite this article:
Sunita N Surse Sushil D Patil Kunal R Deshmukh Sanjay J Kshirsagar. Development and Validation of Analytical Method by RP-HPLC and Forced Degradation Studies of Tioconazole Drug. Asian J. Pharm. Ana. 2019; 9(4):229-231. doi: 10.5958/2231-5675.2019.00039.5


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DOI: 10.5958/2231–5675 

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