Author(s): M. T. Mohite, V. V. Dudhabale, K. V. Chandgude

Email(s): vaishududhabale1995@gmail.com

DOI: 10.5958/2231-5675.2019.00025.5   

Address: M. T. Mohite1, V. V. Dudhabale2*, K. V. Chandgude2
1Department of Pharmaceutical Chemistry, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.
2Department of Pharmaceutical Quality Assurance, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 9,      Issue - 3,     Year - 2019


ABSTRACT:
A simple and precise method was developed for the assay of Ivabradine from SR tablet formulation. The solvent system and wavelength were optimized in order to maximize the sensitivity of the proposed method; Ivabradine shows the maximum absorbance at 286 nm. The separation was achieved on RP-HPLC Isocratic system equipped with HPLC Agilent 1100 series. The mobile phase was prepared with buffer pH 5.8: Acetonitrile: Methanol in the ratio of 65:25:10 o-phosphoric acid used for the pH adjustment (pH-5.8). The method was validated for accuracy, precision, linearity, Specificity, stressed studies, robustness, etc. Linearity was observed in the concentration range of 70-130%and gave mean correlation coefficient 0.999. The developed RP-HPLC method was found to be accurate, precise and was successful applied to a pharmaceutical tablet formulation for qualitative estimation of Ivabradine.


Cite this article:
M. T. Mohite, V. V. Dudhabale, K. V. Chandgude. Validation of Stability Indicating RP-HPLC, Method of Analysis for assay of Ivabradine HCl in SR Tablet. Asian J. Pharm. Ana. 2019; 9(3):133-137. doi: 10.5958/2231-5675.2019.00025.5


Recomonded Articles:

Author(s): Sushil D. Patil, Sunil V. Amurutkar, C.D. Upasani

DOI: 10.5958/2231-5675.2016.00030.2         Access: Open Access Read More

Author(s): Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V

DOI:         Access: Open Access Read More

Author(s): G. Krishnamoorthy, C. Diana Priyadarshini, R. Senthamarai

DOI:         Access: Open Access Read More

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/2231-5675.2017.00020.5         Access: Open Access Read More

Author(s): Pinaz A. Kasad, K.S. Muralikrishna

DOI:         Access: Open Access Read More

Author(s): P. Janaki Pathi, N. Appala Raju, G.Parvathalu

DOI:         Access: Open Access Read More

Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

DOI: 10.5958/2231-5675.2015.00025.3         Access: Open Access Read More

Author(s): B. Thangabalan, M. Salomi, N. Sunitha, S. Manohar Babu

DOI:         Access: Open Access Read More

Author(s): Khushboo Patel*, Dhara Patel, Jaya Dwivedi, Priyanka Newal, Dhananjay Meshram

DOI: 10.5958/2231-5675.2017.00039.4         Access: Open Access Read More

Author(s): Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar

DOI: 10.5958/2231-5675.2018.00008.X         Access: Open Access Read More

Author(s): Saroj Kumar Raul, Bukkuru Spandana, Patibandla Sameera, Vegiraju Vikitha

DOI:         Access: Open Access Read More

Author(s): S. Vidyadhara, RLC Sasidhar, B. Venkateswara Rao, P. Ratna Kumari

DOI:         Access: Open Access Read More

Author(s): Shobha Rani G, Lohita M, Jaya Preethi P, Madhavi R, Sunisitha B, Mounika D

DOI:         Access: Open Access Read More

Author(s): Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D.

DOI: 10.5958/2231-5675.2015.00008.3         Access: Open Access Read More

Asian Journal of Pharmaceutical Analysis (AJPA) is an international, peer-reviewed journal, devoted to pharmaceutical analysis...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5675 

Popular Articles


Recent Articles




Tags