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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Compatibility Study of Ambroxol HCl Drug-Excipients by Using IR Spectroscopy
S. J. Daharwal
Rajendra K. Jangade
Veena Devi Thakur
Bhanu Pratap Sahu
Dr. S. J. Daharwal*, Rajendra K. Jangade, Veena Devi Thakur and Bhanu Pratap Sahu
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) India
Compatibility must be established between the active ingredient and other excipients to produce a stable efficacious, attractive and safe product. In this report FTIR studies were performed and major peaks were determined by the (FTIR-8400S Shimadzu, Japan) will show band shift and broadening compared to the spectra of pure drug. To study the interaction between AmbroxolHCl, selected excipients (sorbitol, mannitol, sucrose).IR spectra of Ambroxol hydrochloride bands were found at 1595-1545 cm-1 for aromatic C=C stretching, 3350-3250cm-1 for aromatic primary amine NH stretch, 3400-3345 cm-1 for intermolecular hydrogen bonded OH stretch and 700-600 cm-1 for C-Br stretching. This confirms the identity of Ambroxol hydrochloride.
Compatibility studies, Ambroxol HCl and excipients.
S. J. Daharwal, Rajendra K. Jangade, Veena Devi Thakur , Bhanu Pratap Sahu. Compatibility Study of Ambroxol HCl Drug-Excipients by Using IR Spectroscopy. Asian J. Pharm. Ana. 3(3): July-Sept. 2013; Page 98-101.
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