Formulation and Evaluation of Herbal Facewash for Acne

 

Mayur N. Ghotkar*, Shubham S. Kharade, Rushikesh S. Chavan, Ranjit S. Jadhav, Nisha M. Jagtap, Ganesh B. Vambhurkar.

 

ABSTRACT:

It is more acceptable to believe that natural remedies are safer with synthetic subjects than with fewer side effects. The global market demand is increasing due to the fusion of herbs. Current work Herbal anti-acne is the development and evaluation of flammable extracts with facial spray containing leaf extract of Tulsi (Ocimum Sanctum),  Hydroalcoholic extract of turmeric (curcuma longa), black pepper, orange peel and nutmeg (myristic aroma) Although there are some specific local herbal formulas available on the market, we propose to make pure herbal formulations without using any artificial ingredient. The plants have been reported in the literature with microorganisms, anti oxidants and anti-inflammatory activity. Several formulas from batch F1 to F5 were created using xanthum gum in several contexts. Color, appearance, stability, fraud, pH and spaghetti were evaluated for various formulations of formulations prepared (F1 to F5). Comparison compared to the market construction of tradable lots. Lot F2 of all formulation studies was optimal for all parameters.

 

 

 

INTRODUCTION:

Acne vulgaris in men is one of the most common skin disorders (Pylosechenesus Unit) that affects at least once in life^[1]. Perennial peaks in adolescence, but the number of men and women between 20 and 30 years of age is also affected by this disorder ^[2].

 

Komedonala pimple, popular, puscataka, and can be classified as a cystic node. These are divided into two types of reproductive komedonala and pimple are: white and yellow. White head (Komedo off) are found in the last colors of purple or white, but if blekaheda vertical barriers (open Komedo) that are currently open meningein hole, sebama dark-colored skin and pholikyulara including salt made of Celso.

 

Pepulasa red, solid, the scope of which appears as a weighted diameter is less than 5 mm. The Pustiels have a miraculous growth of the skin. Cysts and ganglia are deep, vertical lesions in the deepest skin and skin tissues. Package 5 mm Lower than the nodal is more than 5 mm.

 

The molecular pathogenesis involves multiple physiological factors, including Follicular Hyperprefrenization, the production of organisms that increase due to high levels of androgens, and the biosystems, subprinteaberanium annees and staphylococcus epidermidis^[3]. The concept of hypotheses is intended to help improve pathogenesis, including the difference between the sensitivity of the target cell, the biomarker, neuroendocrine, genetic and environmental factors. There are significant beneficial effects in Vulgaris on the many pimples in herbal and synthetic components^{[4][5 ]}.

 

 

 

They may have different mechanism like,

·      Control sebum secretion.

·      Antibiotics which inhibits Propionoibacterium acne and Staphylococcus epidermidis, the main causative organism of acne.

·      Keratolytic which removes the keratin layer and prevents the trapping of sebum under the skin.

·      Anti-inflammatory which prevents the worsening of condition due to inflammation or redness etc.

 

 

There are a number of fuses for futures available in the market for various pharmaceutical ingredients. The technical formulations available in the market are the following: gel, cream, lotion, face wash or cloner, face mask or mask. Tulsi^[6][7] (ocimum sanctum, lamiaceae), turmeric (Curcuma longa) and nutmeg (Myristica fragrance, Myristicaceae). The microorganisms, anti-inflammatory and antioxidant functions of various chemical agents have found a very beneficial effect on pimples ^[8].

MATERIALS:

Table 1: List of ingredients

Sr. No.	Ingredients	Uses
1	Tulsi(ocimum sanctum)	It purifies the blood from toxins and prevents appearance of acne and pimples.
2	Turmeric (Curcuma longa)	The anti-inflammatory qualities can target your pores and calm the skin.Turmeric is also known to reduce scarring.
3	Shahi jeera	As perfume.
4	Lemon juice	To reduce blurring or lack of definition of the skin. Due to the treatment of roots and murals, it is also effective. As a natural pH adjuster in cosmetics
5	Nutmeg seed (Myristica fragrance)	Antibacterial, anti-inflammatory, antiseptic, bactericide
6	Xanthan Gum	Pure carbohydrate culture is also known as corn sugar gum, which is made by fermentation. It is used as a stabilizer and a non-toxic thickener.
7	Liquorice root (Glycyrrhiza glabra)	Give precious property to precious skin. Very resuscitation and nutritional qualities are the attributes.
8	Orange peel extract	Anti oxidants, anti-inflammatories, antimicrobial microbials The acidic properties of orange acid can maintain the natural balance of the skin oil and harden the skin by eliminating the excessive absorption of oil and dead skin cells.
9	Honey	The sand, lotion and light lotion give you bodily fluids like an elephant and a nourishing substance used as a liquid-looking agent.
10	Rose water	Used as solvent; it also has antibacterial and antiseptic properties which eventually cure acne
11	Walnut	Scraping Granule Scraping Action helps in the disinfection of soft oils and cleans dead skin cells and debris.

 

Table 2: Composition of developed formulation

Sr.No.	Ingredients	Quantity taken for 10 g gel
		F1	F2	F3	F4	F5
1	Tulsi(ocimum sanctum)	0.25 ml	0.25 ml	0.25 ml	0.25 ml	0.25 ml
2	Turmeric (Curcuma longa)	0.2 ml	0.25 ml	0.5 ml	0.2 ml	o.2 ml
3	Shahi jeera	0.15 ml	0.15 ml	0.15 ml	0.15 ml	0.15 ml
4	Lemon juice	0.15 ml	0.15 ml	0.15 ml	0.15 ml	0.15 ml
5	Nutmeg seed (Myristica fragrance)	0.7 ml	0.27 ml	0.52 ml	0.27 ml	0.27 ml
6	Xanthan Gum	0.05 g	0.1 g	0.15 g	0.02 g	0.01 g
7	Liquorice root (Glycyrrhiza glabra)	0.3 ml	0.3 ml	0.3 ml	0.3 ml	0.3 ml
8	Orange peel extract	0.25 ml	0.25 ml	0.25 ml	0.25 ml	0.25 ml
9	Honey	0.5 ml	0.5 ml	0.5 ml	0.5 ml	0.5 ml
10	Rose water	q.s.	q.s.	q.s.	q.s.	q.s.
11	Walnut	q.s.	q.s.	q.s.	q.s.	q.s.

 

Marketed Formulation:

Himalaya Purifying neem face wash was purchased from local market, Sangli.

 

EVALUATION OF FORMULATION:

Physical evaluation:

Physical parameters, such as color, appearance and consistency, are examined for people with visual impairment.

 

Washability:

The formulation has been used on the skin and then easily verified after washing with water.

pH:

Using a digital pH meter calibrated at constant temperature, the pH of 1% of the hydro transpiration is calculated^[9].

 

Spreadability:

Spredabibiliti indicate the limit of the area in which the gel spreads easily on the skin or the affected part. The biological availability of the functionality to create a gel also depends on the value of the extension ^{[10] [11]}. By slides spelabiliti two seconds, put the second slide to slide out of jail, it shows below a certain weight. Reduce the time needed to separate the two slides, a good spreadability. Two standard sizes of standard glass were taken. Herbal gel was designed in one of the slides. The other was placed on top of the slide gel, like a gel sandwich between the two slides on the 6-centimeter slide on the slide. The weight of 100 gms was placed in the upper slide so that the gel between the two slides were pressed evenly with a thin layer. The weight was eliminated and eliminated much more than the prisons that adhere to the slides. In the position, two slides are placed without interruption, thus remaining in such a way that, in this way, the weight of the body built in the upper slide is like a free dream. A weight of 20 gm was built in the upper slide. The time needed for the previous slide is to go to a distance of 6 cm 7, separated from the next slide by the weight of the weight. This experiment was performed three times in the average time taken ^{[12] [13]} to gel and commercialize gels and calculate three times.

 

Spreadability was calculated by using the following formula,

 

S=M×L/T

 

Where,

S-Spreadability

M-Weight tied to the upper slide (20gm).

L-Length of the glass (6.5cm).

T-Time in sec.

 

RESULT AND DISCUSSION:

The results of the evaluation are shown in Table 2. The formulation was bright orange, but the marketing was green. Semi-code compatibility is found in the formula F1, F2, F3 and F4. All the formulations are identical, they wash easily. All the formulas had a slightly alkaline pH that is compatible with the normal physiology of the skin.

 

Table 3: Evaluation of formulations

Formulation/Batch(Code)	Colour	Consistency	Washability	pH	Spreadability (gm-cm/sec)
Marketed	Green	Semi-solid	Good	5.3	4.803
F1	Orange	Semi-solid	Good	4.4	3.875
F2	Orange	Semi-solid	Good	4.8	4.465
F3	Orange	Semi-solid	Good	4.9	1.742
F4	Orange	Semi-solid	Good	4.4	1.987
F5	Orange	liquid	Good	4.1	3.539

 

All batches F1, F2 and F5 had the optimum spreading capacity. The batch of formulation F2 comparatively shows more spaghetti than the batch of formulas F1, F3, F4 and F5. And according to the parameters of lot F2, similar results were found near the market instructions and, therefore, lot F2 was completed.

 

CONCLUSION:

It is more acceptable to believe that natural remedies are safer with synthetic subjects than with fewer side effects. The global market demand is increasing due to the fusion of herbs. It is a very good effort to establish an herbal facial wash, which includes Tulsi leaves, turmeric rhizomes, rooted roots and aqueous extracts of nutmeg. In this study, it was found that the herbal fixation developed from Batch F2 would be relatively better than other formulations.

 

ACKNOWLEDGEMENT:

We, the authors, are very much thankful to Dr. M. A. Bhutkar for their valuable guidance and technical suggestions and also for their support to make this article with full of information in every aspect.

 

REFERENCES:

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Received on 09.09.2018       Accepted on 19.10.2018     

© Asian Pharma Press All Right Reserved

Asian J. Pharm. Ana. 2018; 8(4): 183-185.

DOI: 10.5958/2231-5675.2018.00033.9