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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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RP-HPLC Method for Estimation of Solifenacin Succinate in API and Tablet Dosage Form
Hemant T Kumar
Srinivasa Y Rao
Vara Prasad K Rao
Bhavana V, Hemant T Kumar*, Srinivasa Y Rao, Vara Prasad K Rao
Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530049
A simple RP-HPLC method was developed and validated for the quantitative estimation of Solifenacin succinate in API and Tablet dosage form. In this method, mobile phase was Acetonitrile and water in the ratio of 80:20 % v/v and at a flow rate of 1.0 ml/min. The optimum wavelength for detection was 225 nm. The column used was Enable ODS reverse phase (250 mm × 4.6 mm, 5 µm particle size) C18 column. The retention time of solifenacin succinate was found at 2.92 min. The linearity was observed in the range of 10–100 µg/ml with the correlation coefficient of 0.998. The proposed method was found to be simple, precise, accurate and selective and can be successfully applied for the routine analysis of Solifenacin succinate in API and tablet dosage form without any interference by the excipients.
Solifenacin Succinate, RP-HPLC, Validation, Tablet dosage form.
Bhavana V, Hemant T Kumar, Srinivasa Y Rao, Vara Prasad K Rao. RP-HPLC Method for Estimation of Solifenacin Succinate in API and Tablet Dosage Form. Asian J. Pharm. Ana. 2019; 9(3):118-122.
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