Volume No. :   9

Issue No. :  3

Year :  2019

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Analytical Techniques for Estimation of Rosiglitazone



Address:   Prashant Rajput, Sandip Firke*
Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India
*Corresponding Author
DOI No: 10.5958/2231-5675.2019.00030.9

ABSTRACT:
Rosiglitazone is a thiazolidinedione class of antidiabetic agent utilized in the treatment of patients having Type 2 diabetes.It works as an insulin sensitizer, by binding to the peroxisome proliferator-activated receptor-? (PPAR?) in fat cells and making the cells more responsive to insulin.The present review highlights the published analytical techniques reported so far in the literatureforthe analysis of rosiglitazone. They include various techniques likevoltammetry, spectrophotometry, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry, capillary electrophoresis-electrospray ionization-mass spectrometry for their routine, impurity profiling and stability indicating determination in different pharmaceutical dosage forms.
KEYWORDS:
Rosiglitazone, Peroxisome proliferator-activated receptor-γ, Stability indicating methods, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry.
Cite:
Prashant Rajput, Sandip Firke. Analytical Techniques for Estimation of Rosiglitazone. Asian J. Pharm. Ana. 2019; 9(3):167-176.
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