Volume No. :   9

Issue No. :  2

Year :  2019

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Forced Degradation Study for Tolterodine by HPLC with PDA Detection



Address:   Tentu Nageswara Rao1*, Imad Hussain1, Y. Prashanthi2, T. B. Patrudu3
1School of Materials Science and Engineering, Changwon National University, Changwon, Gyeongnam, 641-773, Republic of Korea.
2Department of Chemistry, Mahatma Gandhi University, Nalgonda, Telangana, India
3Department of Chemistry, Gitam University, Hyderabad Campus, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2019.00015.2

ABSTRACT:
A simple and inexpensive method was developed with high performance liquid chromatography with PDA detection for determination of Tolterodine. The chromatographic separations were achieved on (250×4.6 mm), 5.0 µm make: X-terra C18 column employing Acetonitrile: 0.1% v/v phosphoric acid in Water (35:65, v/v) as mobile phase with gradient programmed at flow rate 1.0 mL/min was chosen. The detector wavelength of 210 nm was employed.
KEYWORDS:
Forced degradation, HPLC, Method validation, Tolterodine.
Cite:
Tentu Nageswara Rao, Imad Hussain, Y. Prashanthi, T. B. Patrudu. Forced Degradation Study for Tolterodine by HPLC with PDA Detection. Asian J. Pharm. Ana. 2019; 9(2):77-81.
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