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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Estimation of Phenyramidol Hydrochloride in Tablet Dosage form and in Bulk Drug by Spectrophotometric Method
Syed Sagheer Ahmed
Vazir Ashfaq Ahmed
Mahaboob Pasha*, Syed Sagheer Ahmed, Mohammed Khaleel, Vazir Ashfaq Ahmed
Department of Pharmaceutical Analysis and Quality Assurance. M.M.U College of Pharmacy, Ramanagara
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation of Phenyramidol Hydrochloride in pure drug and tablet dosage form. The absorbance was measured at 236nm using distilled water as a solvent system. It obeyed Beer’s law at the concentration range of 2-18µg/ml with a coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 1.224µg/ml and Limit of quantitation (LOQ) was found to be 5.222µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness, and ruggedness. It was also found that the excipients present in the commercial formulation did not interfere with the method. The proposed method can be utilized for routine quantitative analysis of Phenyramidol Hydrochloride.
Phenyramidol hydrochloride, Analgesic, Spectrophotometry, Method validation.
Mahaboob Pasha, Syed Sagheer Ahmed, Mohammed Khaleel, Vazir Ashfaq Ahmed. Estimation of Phenyramidol Hydrochloride in Tablet Dosage form and in Bulk Drug by Spectrophotometric Method. Asian J. Pharm. Ana. 2019; 9(2):55-61.
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