Volume No. :   9

Issue No. :  2

Year :  2019

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Eco-Friendly Spectrophotometric Estimation of Gliclazide using Hydrotropic Solubilization Technique



Address:   Satheesh Kumar G1*, Ajay Kumar D2, M Niranjan Babu1, Subhashis Debnath1, B Ishwarya2, G Jyothi2, D Shravan Kumar2, P Bhavani2, D Anjiah2, G Sandeep Kumar2
1Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Chittoor District, Andhra Pradesh-517561.
2Department of Pharmaceutical Chemistry, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet, (M) Medchal District, Telangana-500101.
*Corresponding Author
DOI No: 10.5958/2231-5675.2019.00010.3

ABSTRACT:
In the projected analysis work, a successful; attempt was made to develop simple, accurate, novel, ecofriendly and precise technique for the estimation of poorly water soluble drug Gliclazide in single drug containing dosage form. In the present investigation, a mixed hydrotropic blend of 2M urea and 6M trisodium citrate was used for quantitative determination. Gliclazide showed ?- max at 225 nm and beer’s law was obeyed with in the concentration range of 4µg/ml –12µg/ml with mean recovery ranging from 95.33% to 96.35%. The developed technique was validated as per ICH guidelines.
KEYWORDS:
Gliclazide, Urea, Trisodium citrate, Hydrotropy.
Cite:
G Jyothi, D Shravan Kumar, P Bhavani, D Anjiah, G Sandeep Kumar. Eco-Friendly Spectrophotometric Estimation of Gliclazide using Hydrotropic Solubilization Technique. Asian J. Pharm. Ana. 2019; 9(2):45-48.
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