Volume No. :   9

Issue No. :  1

Year :  2019

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Ecofriendly Validated Spectrophotometric Method for the Estimation of Amlodipine Besylate by using Hydrotropic Solubilization Method



Address:   Akshay Waghmare1, Ganesh Taware2, Shrikrishna Baokar1*, Santosh Undare3
1Department of Pharmaceutical Chemistry, SVPM’S College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra 413115.
2Department of Pharmaceutics, SVPM’S College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra 413115.
3PG Department of Chemistry, Balbhim Arts, Science and Commerce College, Beed, Maharashtra 431122.
*Corresponding Author
DOI No: 10.5958/2231-5675.2019.00003.6

ABSTRACT:
Simple sensitive and accurate spectrophotometric methods were developed for determination of poorly water soluble Amlodipine Besylate in pure and pharmaceutical dosage form using hydrotropic agents ammonium acetate. Hydrotropy is a good choice for replacing organic solvents used for this kind of drugs to reduce the cost and hazards of the analytical method. Amlodipine Besylate shows maximum absorption at 362 nm in 0.5 M of the hydrotropic agents. Beer’s law was found to be obeyed in the concentration range of 5 - 25 µg/mL for the hydrotrope. Limit of detection was found to be 1.102µg/mL and limit of quantification was 3.278 µg/mL for ammonium acetate. The results were in a good agreement with those obtained with official USP method.
KEYWORDS:
Spectrophotometric Method, Amlodipine Besylate .
Cite:
Akshay Waghmare, Ganesh Taware, Shrikrishna Baokar, Santosh Undare. Ecofriendly Validated Spectrophotometric Method for the Estimation of Amlodipine Besylate by using Hydrotropic Solubilization Method. Asian J. Pharm. Ana. 2019; 9(1):08-10.
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