Volume No. :   9

Issue No. :  1

Year :  2019

ISSN Print :  2231-5667

ISSN Online :  2231-5675


Registration

Allready Registrered
Click to Login

Validated Derivative Spectrophotometric method for simultaneous estimation of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride from tablet formulations



Address:   G. K. Dyade
SVPM’s College of Pharmacy, Malegaon (BKII), Baramati, Dist. Pune-413115
*Corresponding Author
DOI No: 10.5958/2231-5675.2019.00001.2

ABSTRACT:
A simple, precise and accurate spectrophotometric method was developed for simultaneous estimation of LevocetirizineDiHCl and Phenylephrine HCl in bulk and tablet dosage form. This method is based on use of derivative method for simultaneous estimation of both the drug from tablet using distilled water as solvent. Phenylephrine HCl shows maximum absorption at 273 nm and LevocetirizineDiHCl shows absorption at 231 nm. Phenylephrine HCL and LevocetirizineHCl obeys Beer’, s law in the concentration range 0-40 µg/ml and 0-30µg/ml respectively. During estimation of Tablet no interference was found from excipients. The dosage form contains 10 mg Phenylephrine HCl and 5 mg LevocetirizineDiHCl. The suitability of this method for estimation of both drugs was proved by validation. Statistical analysis of data shows that the developed method is sound under analytical condition and can be used for routine analysis of both drugs.
KEYWORDS:
Phenylephrine HCl (PHE), LevocetirizineDiHCl (CET), Validation, Ultraviolet (UV), Nanometer(nm), Concentration (Conc.)
Cite:
G. K. Dyade. Validated Derivative Spectrophotometric method for simultaneous estimation of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride from tablet formulations. Asian J. Pharm. Ana. 2019; 9(1):01-04.
[View HTML]     



Visitor's No. :   168717