Volume No. :   8

Issue No. :  2

Year :  2018

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Method Development and Validation of Cilazapril in Bulk Formulation by FC Reagent



Address:   Chavi Dagar*, G. Rohit Reddy, T. Ramesh
Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2018.00016.9

ABSTRACT:
A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with FC Reagent [Folin Ciocalteu] in the presence of Sodium Carbonate producing blue colour which shows maximum absorbance at 725nm against reagent blank. The Chromogen obeyed Beer’s law in the concentration range of 10-50 µg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.
KEYWORDS:
Cilazapril, FC Reagent, Sodium Carbonate, Visible Spectrophotometric.
Cite:
Chavi Dagar, G. Rohit Reddy, T. Ramesh. Method Development and Validation of Cilazapril in Bulk Formulation by FC Reagent. Asian J. Pharm. Ana. 2018; 8(2): 83-85.
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