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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Motor Neurone Disease: Treatment by Modern and Conventional Medicines
NKBR College of Pharmacy and Research Centre, Meerut
Motor neuron disease (MND) is a neurodegenerative disease. It is a fatal and progressive disease that attacks specific nerve cells (motor neurons) in the spinal cord and the brain. Motor neurons control the voluntary movement of muscles. MND is also known as Lou Gehrig´s disease, maladie de Charcot and amyotrophic lateral sclerosis (ALS).‘Amyotrophic’ refers to the loss of muscle mass; ‘lateral’ refers to the nerve tracks that run down both sides of the spinal cord, where many of the neurons affected by MND are found; ‘sclerosis’ refers to the scar tissue that remains after the nerves damage. Motor neurons reach to the spinal cord from brain and to the muscles throughout the body from spinal cord. When motor neurons are not working, the capacity of the brain to initiate and control muscle movement is lost. Patients are often initially prompt¬ed to seek medical advice because of a persistent muscle twitch, muscle fatigue, or even muscle wasting. This generally initiates in the hands or lower legs, frequently accompanied by cramps. As MND progresses, patients lose the ability to dress and feed themselves, sit up, walk, or even speak. The bodily functions that remain intact until or near death are the control of urination and bowel movements, sexual function, eye movement, and intellect. Gen¬erally, patients survive three to five years after diagnosis. Death generally occurs due to respiratory failure. MND is most common in the age range of 40 to 70 years and about 20 per cent more common in men than in women. The cause of the disease is still unclear. Present treatment of MND is aimed at symptomatic relief, prevention of complica¬tions and maintenance of optimal function and optimal quality of life. Researchers have shown that the antibiotic stops “cell suicide” (neuronal apoptosis). Apoptosis includes the activa¬tion of nitric oxide and caspase enzyme. The present paper includes the information about the possible treatment of MND by herbal medicines.
MND, Amyotrophic lateral sclerosis, Motor neurons, Herbal drug.
Alimuddin Saifi. Motor Neurone Disease: Treatment by Modern and Conventional Medicines. Asian J. Pharm. Ana. 2018; 8(2):117-122.
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