Volume No. :   8

Issue No. :  1

Year :  2018

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Application of Area Under Curve Technique for UV- Spectrophotometric Determination of Luliconazole in Bulk and Pharmaceutical Formulation



Address:   Mansi J. Chaudhari1, Suraj R. Chaudhari2, Shailesh S. Chalikwar3, Atul A. Shirkhedkar4*
1M. Pharm. Student, Department of Quality Assurance, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 424 405
2Assistant Professor, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 424 405
3Professor and Head, Department of Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 425 405
4*Vice-Principal and Head, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule (MS) 425 405
*Corresponding Author
DOI No: 10.5958/2231-5675.2018.00008.X

ABSTRACT:
A simple, rapid, accurate and economical UV- spectrophometric method has been developed for estimation of Luliconazole in bulk and formulation using area under curve (AUC) technique. The method applied was an area under curve (AUC) in which area under curve was integrated in the wavelength range of 279 – 305 nm. The ? max of Luliconazole in methanol was found to be 295 nm. The drug follows linear in the concentration range 3-18 µg/mL with correlation coefficient value 0.997. The proposed method was applied for qualitative and quantitative estimation of Luliconazole in pharmaceutical formulation and results were found in good agreement with the label claimed. This developed method can be used for routine analysis of Luliconazole in bulk and formulation.
KEYWORDS:
Luliconazole, UV-Spectrophotometry, Area under Curve, Validation, ICH guidelines
Cite:
Mansi J. Chaudhari, Suraj R. Chaudhari, Shailesh S. Chalikwar, Atul A. Shirkhedkar. Application of Area Under Curve Technique for UV- Spectrophotometric Determination of Luliconazole in Bulk and Pharmaceutical Formulation. Asian J. Pharm. Ana. 2018; 8(1):45-48.
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