Volume No. :   8

Issue No. :  1

Year :  2018

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Development and Validation of Q-Absorbance UV Spectrophotometric Method for Simultaneous estimation of Amlodipine Besylate and Candesartan Cilexetil In bulk drugs



Address:   Prof. Sushil D. Patil*, Rohit B. Badhan*, Dr. Sanjay J. Kshirsagar.
MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra State 422003, India
*Corresponding Author
DOI No: 10.5958/2231-5675.2018.00010.8

ABSTRACT:
A new, simple, accurate and sensitive UV-spectrophotometric absorption correction method has been developed for simultaneous determination of Candesartan Cilexetil and Amlodipine Besylate in bulk utilizing concept of standard addition. The method is based upon determination of Amlodipine Besylate at 237 nm & Candesartan Cilexetil at 254 nm methanol as a solvent. Overlay spectra of both drugs shows absorbance at 244 nm. Linearity was observed in range of 10-60 µg/ml and 2-10 µg/ml for Candesartan Cilexetil and Amlodipin Besylate respectively. The correlation coefficient value was found to near to 1. All methods were statistically validated as per ICH guidelines.
KEYWORDS:
Candesartan Cilexetil, Amlodipine Besylate, UV-spectrophotometric, Simultaneous estimation, Method Development and Validation, ICH Guideline.
Cite:
Sushil D. Patil, Rohit B. Badhan, Sanjay J. Kshirsagar. Development and Validation of Q-Absorbance UV Spectrophotometric Method for Simultaneous estimation of Amlodipine Besylate and Candesartan Cilexetil In bulk drugs. Asian J. Pharm. Ana. 2018; 8(1): 53-57.
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