Volume No. :   7

Issue No. :  4

Year :  2017

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Synthesis of 2-(3-Substitutedamino-2,4-Dithiobiuretoformamidino-4-isobutoxyphenyl)-4-Methyl-5-Carboxy-1,3-Thiazoles



Address:   A. S. Shendge, D. T. Tayade*, P. R. Kale
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati 444604.
*Corresponding Author
DOI No: 10.5958/2231-5675.2017.00034.5

ABSTRACT:
A novel method has been developed for the synthesis of 2-(3-substitutedamino-2,4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.
KEYWORDS:
2-(3-Substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1,3-thiazoles, ethanol, acetone.
Cite:
A. S. Shendge, D. T. Tayade*, P. R. Kale. Synthesis of 2-(3-Substitutedamino-2,4-Dithiobiuretoformamidino-4-isobutoxyphenyl)-4-Methyl-5-Carboxy-1,3-Thiazoles. Asian J. Pharm. Ana. 2017; 7(4): 214-217.
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