Volume No. :   7

Issue No. :  3

Year :  2017

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Simultaneous Formulation, Evaluation and estimation of controlled release of NSAID Drug



Address:   Nuha Rasheed1*, Abdul Saleem Mohammad2, Hajera Hafeez3, Seema Farheen4
1Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, India.
2Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, India.
3Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Rangareddi (Dist)-501504, Telangana, India.
4Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2017.00028.X

ABSTRACT:
The objective of the study was to prepare and evaluate ACS contain pellets by the process of extrusion followed by spheronization for controlled release. The method employed was economical and does not imply the use of toxic solvents. The aqueous SLS which forms micropores on the surface of the pellets. The results of micromeritic properties, Hausner ratio and friability of the pellets were well within the limits which indicate good flow potential for the prepared pellets. Drug contains pellets exhibited spherical nature as evidenced by SEM photomicrographs and sphericity studies. From the FTIR and DSC studies, it was observed that there was no chemical interaction between the drug and polymers used indicates that drug was in stable form. The drug content study revealed uniform distribution of the drug in the pellets. The drug release rate was found vary among the formulations depending on the compositions of polymers used. The obtained dissolution data indicated that the drug release through the microporous polymeric membrane follows Fickian diffusion. Optimized formulation F5 and marketed product Aceton SR100 mg tablet showed similarity in drug release profile. Formulation F5 is an ideal formulation for once daily administration. From the present study, it can be concluded that the prepared matrix pellets demonstrate the potential use of SA/GPS/MCC blend for the development of controlled drug delivery systems for many water insoluble drug.
KEYWORDS:
Aceclofenac, NSAID, surfactants, formulation, lipophilic, hydrophilic, gastrointestinal fluid (GIF).
Cite:
Nuha Rasheed, Abdul Saleem Mohammad, Hajera Hafeez, Seema Farheen. Simultaneous Formulation, Evaluation and estimation of controlled release of NSAID Drug. Asian J. Pharm. Ana. 2017; 7(3): 176-184.
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