Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5667

ISSN Online :  2231-5675


Registration

Allready Registrered
Click to Login

Identification of Impurities and Degradation Products in Pharmaceutical Products- Role of Hyphenated Techniques



Address:   Hamid Khan1*, Javed Ali2
1JK College of Pharmacy, Bilaspur, CG, India-495001
2Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India-110062
*Corresponding Author
DOI No: 10.5958/2231-5675.2017.00006.0

ABSTRACT:
Impurity profiling and identification of degradation product is an essential part of pharmaceutical development program. Impurity profiling is mandatory requirement by various regulatory agencies and is directly related with the quality, safety and efficacy of a drug product. The ultimate purpose of impurity profiling and stress testing is in the establishment of the degradation products pathways and to investigate the stability-indicating power of the analytical procedures which is ultimately helpful in the prediction of shelf life of drug product. Hyphenated technique is combination a combination of two different analytical techniques with the help of proper interface. Mainly chromatographic techniques are combined with the spectroscopic techniques. This write up provides a review on brief information about role of different hyphenated analytical techniques such as HPLC-UV, HPLC-MS, GC-MS and UPLC-MS/MS for identification of impurities and degradation products in pharmaceutical products.
KEYWORDS:
Identification, Impurities, Degradation Products, Stress Testing, Analytical Techniques.
Cite:
Hamid Khan, Javed Ali. Identification of Impurities and Degradation Products in Pharmaceutical Products- Role of Hyphenated Techniques. Asian J. Pharm. Ana. 2017; 7(1): 31-35.
[View HTML]      [View PDF]



Visitor's No. :   80018