Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Development and Validation of Simple UV- Spectrophotometric Method for the Determination of Empagliflozin



Address:   Sushil D. Patil*, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.
MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra State 422003, India
*Corresponding Author
DOI No: 10.5958/2231-5675.2017.00004.7

ABSTRACT:
A rapid, specific and economic UV Spectrophotometric method has been developed using a solvent composed of water: methanol (9.0:1.0) to determine the empagliflozin content in bulk. At a pre-determined ?max of 224 nm, it was proved linear in the range of 1.0–3.0 µg/mL, and exhibited good correlation coefficient (R2=0.998) and minimum sum of square error 0.0595, Hence we have selected equation of line of 50-90% (best fit line) linearity throughout experiment. The method was validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that the method can be employed for the routine analysis of empagliflozin in bulks as well as in the commercial formulations.
KEYWORDS:
UV, Empagliflozin, Method Development and Validation, ICH Guideline.
Cite:
Sushil D. Patil, Sayali K. Chaure, Maswood Ahmed Hafizur Rahman, Prajkta U. Varpe, Sanjay Kshirsagar.. Development and Validation of Simple UV- Spectrophotometric Method for the Determination of Empagliflozin. Asian J. Pharm. Ana. 2017; 7(1): 18-22.
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