Volume No. :   7

Issue No. :  1

Year :  2017

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Development and Validation of Visible Method for Estimation of Cilazapril in Bulk Formulation by MBTH Reagent



Address:   Chavi Dagar, G. Rohit Reddy*, VVS. Rajendra Prasad
Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2017.00003.5

ABSTRACT:
A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with MBTH Reagent [3-Methyl-2-Benzothiazolinone Hydrazone] in the presence of Ferric chloride producing greenish yellow colour chromogen which shows maximum absorbance at 402nm against reagent blank. The Chromogen obeyed Beer’s law in the concentration range of 10-50 µg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.
KEYWORDS:
Cilazapril, MBTH Reagent, Ferric chloride, Visible Spectrophotometric.
Cite:
Chavi Dagar, G. Rohit Reddy, VVS. Rajendra Prasad. Development and Validation of Visible Method for Estimation of Cilazapril in Bulk Formulation by MBTH Reagent. Asian J. Pharm. Ana. 2017; 7(1): 15-17.
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