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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Development and Validation of analytical method for Simultaneous estimation of Ornidazole and Cefixime trihydrate tablet dosage forms by UV spectroscopy
Dr. S.Selvakumar1*, Dr. S. Ravichandran2, L. Matsyagiri1
1Swami Vivekananda Institute of Pharmaceutical Sciences, Vangapally (V), Yadagirigutta (M), Nalgonda (Dt), Telangana –508 286, India.
2P.S.V. College of Pharmaceutical Science and Research, Orappam Village, Bargur (Tk), Krishnagri (Dt), Tamilnadu –635108, India.
A simple, specific, accurate, precise and economic Simultaneous spectrophotometric method in UV region have been developed for the determination of Ornidazole and Cefixime in bulk and pharmaceutical tablet formulations. The optimum conditions for the analysis of the drug were established. Linearity was found over the concentration range of 5-30 µg/ml for Ornidazole and 2-20 µg/ml for Cefixime. The Simultaneous UV method has been successfully applied for the analysis of drugs in tablet formulation. The results of the tablet analysis were in the range of 99.57 to 100.2 % for Ornidazole and 99.25 to 100.8 % for Cefixime, which indicated repeatability of the method. The percentage recoveries were found be 100.3 % for both the drugs indicated that the Simultaneous UV method is precise and reproducible. The Ruggdness Interday variation were found be in mean of 100.25 for Ornidazole and 99.85 for Cefixime. The Ruggedness Intraday Variation were found be in mean of 100.2 for Ornidazole and 100.18 for Cefixime.
Ornidazole, Cefixime, UV-Visible Spectroscopy, Simultaneous method.
S.Selvakumar, S. Ravichandran, L. Matsyagiri. Development and Validation of analytical method for Simultaneous estimation of Ornidazole and Cefixime trihydrate tablet dosage forms by UV spectroscopy. Asian J. Pharm. Ana. 2016; 6(4): 246-252.
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