Volume No. :   6

Issue No. :  3

Year :  2016

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Simultaneous Formulation, Estimation and Evaluation of Ofloxacin Microbeads



Address:   Chandana Pasupuleti1, Abdul Saleem Mohammad2*, Nuha Rasheed3, Kathula Umadevi2, Duggi Adilakshmi1
1Department of Pharmaceutics, St. Mary’s Pharmacy college, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
2Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
3Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2016.00026.0

ABSTRACT:
The aim for the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increasing local action in gastric region against Helicobacter pylori. Therefore the present investigation is concerned with the development of rice bran oil entrapped zinc pectinate beads containing ofloxacin, which after oral administration were designed to prolong the gastric residence time, thus to increase the bioavailability of the drug. A suitable method of analysis of drug by UV spectrophotometry was developed. Ofloxacin showed maximum absorption at a wavelength 294.5 nm in pH 1.2 hydrochloric acid buffer. The value of regression coefficient (r2) was found to be 0.999, which showed linear relationship between concentration and absorbance. Preformulation study for drug and polymer compatibility by DSC and FTIR gave confirmation about the purity of the drug and showed no interaction between drug and the polymers.
KEYWORDS:
Ofloxacin, buffer, DSC, FTIR, bioavailability, microbeads.
Cite:
Chandana Pasupuleti, Abdul Saleem Mohammad, Nuha Rasheed, Kathula Umadevi, Duggi Adilakshmi. Simultaneous Formulation, Estimation and Evaluation of Ofloxacin Microbeads. Asian J. Pharm. Ana. 2016; 6(3): 167-182.
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