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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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UV Spectrophotometric Method Development and Validation for the Estimation of Valsartan in Bulk and Pharmaceutical Dosage Form
Saroj Kumar Raul
Gopal Krishna Padhy
Pramudula Ramya Krishna
Boddu Uma Madhu Priya
Saroj Kumar Raul*, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya
Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India
A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The ?max of valsartan in methanol and water was found to be 248.21 nm. Methanol and water is used as diluent in equal proportion. The drug exhibited the linearity in the concentration range of 2-20µg/ml with correlation coefficient of 0.999. The % recovery of the drug for the proposed was found to be 99.2%. The limit of detection and limit of quantification was found to be 0.15% and 0.45% respectively. No interference was observed in the presence of common pharmaceutical excipient. The method was validated as per ICH guidelines. The developed method was successfully employed for the estimation of valsartan in pharmaceutical dosage form.
Valsartan, UV Spectroscopy, Method development, Validation, Estimation.
Saroj Kumar Raul, Gopal Krishna Padhy, Pramudula Ramya Krishna, Boddu Uma Madhu Priya. UV Spectrophotometric Method Development and Validation for the Estimation of Valsartan in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Ana. 2016; 6(3):147-150.
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