Volume No. :   6

Issue No. :  2

Year :  2016

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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UV Spectrophotometric Method for Estimation of Eprosartan Mesylate in Bulk and in Pharmaceutical Formulation



Address:   Pandya Dimple Bhupendra1*, Shinkar Dattatraya Manohar2, Saudagar Ravindra Bhanudas3, Bacchav Jyoti Kailas4
1Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra.
3Department of Pharmaceutics, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra.
4Department of Pharmaceutical Chemistry, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra.
2Department of Quality Assurance Techniques, KCT’s R.G.S. College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra.
*Corresponding Author
DOI No: 10.5958/2231-5675.2016.00018.1

ABSTRACT:
UV Spectrophotometric method provides a simple, efficient, precise and accurate method for development and validation of Eprosartan mesylate in bulk and its tablet formulation. The present study is based on measurement of the absorbance of Eprosartan mesylate solution in methanol: phosphate buffer pH 7.4 (10:90) at 293 nm in wavelength length of 200-400nm. Beers law was observed in the range of 5-25 ppm for this method. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification which proves the suitability of this method for estimation of EPM in bulk and its tablet formulation. Results of recovery studies shows that the method was not affected by the presence of common excipients in tablets. Thus the method was found to be simple, economical, accurate and reproducible.
KEYWORDS:
Eprosartan mesylate, UV Spectrophotometry, phosphate buffer ph7.4.
Cite:
Pandya Dimple Bhupendra, Shinkar Dattatraya Manohar, Saudagar Ravindra Bhanudas, Bacchav Jyoti Kailas. UV Spectrophotometric Method for Estimation of Eprosartan Mesylate in Bulk and in Pharmaceutical Formulation. Asian J. Pharm. Ana. 2016; 6(2): 119-121.
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