Volume No. :   6

Issue No. :  1

Year :  2016

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Development and Validation of Analytical Method for Aripiprazole and Escitalopram Oxalate by Simultaneous Equation Spectroscopic Method



Address:   Divya Solanki1,2*, Hasumati Raj2, Neelam Prajapati2
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat
*Corresponding Author
DOI No: 10.5958/2231-5675.2016.00007.7

ABSTRACT:
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Aripiprazole and Escitalopram Oxalate in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 255.00 nm and 238.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 5-30 µg/ml and 15-75 µg/ml at their respective ?max. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.129 and 0.223µg/ml Aripiprazole and Escitalopram Oxalate, respectively. The limit of quantification was 0.392 and 0.677 for Aripiprazole and Escitalopram Oxalate, respectively. Recovery of Aripiprazole and Escitalopram Oxalate in were found to be 100.66 % and 100.70 % respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.
KEYWORDS:
Aripiprazole, Escitalopram Oxalate, simultaneous estimation, Simultaneous equation method, analysis method.
Cite:
Divya Solanki, Hasumati Raj, Neelam Prajapati. Development and Validation of Analytical Method for Aripiprazole and Escitalopram Oxalate by Simultaneous Equation Spectroscopic Method. Asian J. Pharm. Ana. 6(1): January- March, 2016; Page 41-46.
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