Volume No. :   5

Issue No. :  4

Year :  2015

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Ranolazine: A Review on Analytical Method and Its Determination in Synthetic Mixture



Address:   Patel Vishakha. D.*, Raj Hasumati
Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat
*Corresponding Author
DOI No: 10.5958/2231-5675.2015.00034.4

ABSTRACT:
Ranolazine is a piperazine derivative is a new anti-ischemic drug for the treatment of angina. Ranolazine is to inhibit late INa thus preventing sodium overload of the cell. As a consequence, ranolazine prevents reverse mode sodium–calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow. This review article represents the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatographic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.
KEYWORDS:
Olmesartan medoxomil, Forced degradation studies, Degradation products, LC, LCMS,NMR, IR and TLC.
Cite:
Patel Vishakha. D., Raj Hasumati. Ranolazine: A Review on Analytical Method and Its Determination in Synthetic Mixture. Asian J. Pharm. Ana. 5(4): 2015; 214-218.
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