Volume No. :   5

Issue No. :  3

Year :  2015

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix



Address:   Paras Virani1,2*, Rajanit Sojitra2, Hasumati Raj2, Vineet Jain2.
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat
*Corresponding Author
DOI No: 10.5958/2231-5675.2015.00025.3

ABSTRACT:
Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.
KEYWORDS:
Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.
Cite:
Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain. Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix. Asian J. Pharm. Ana. 5(3): July- Sept. 2015; Page 151-160.
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