Volume No. :   5

Issue No. :  3

Year :  2015

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Estimation of Venlafaxine in Commercial Dosage Forms Using Simple and Convenient Spectrophotometric Method



Address:   Humera Pathan1, Shrikrishna Baokar1*, Undare Santosh2, Patil R.N.1
1Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra, India 413115
2PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India 431112.
*Corresponding Author
DOI No: 10.5958/2231-5675.2015.00023.X

ABSTRACT:
Venlafaxine belongs to a group of Antidepressant with a novel chemical structure. In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of absorbance of Venlafaxine hydrochloride solution in 0.1N NaOH at 225 nm. The method obeys Beer’s Lambert’s law in the selected concentration range 5-25 µg/ml in selected solvent. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of venlafaxine hydrochloride in bulk and pharmaceutical formulations.
KEYWORDS:
UV-visible spectrophotometer, Method development, Venlafaxine hydrochloride
Cite:
Humera Pathan, Shrikrishna Baokar, Undare Santosh, Patil R.N.. Estimation of Venlafaxine in Commercial Dosage Forms Using Simple and Convenient Spectrophotometric Method. Asian J. Pharm. Ana. 5(3): July- Sept. 2015; Page 142-146.
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