Registered User Login
Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
Home
|
About AJPA
|
Current Issue
|
Archives
|
Editorial Board
|
Instructions
|
Paper Submission
|
News & Conferences
|
Subscription
|
Corrigendum
|
Contact Us
Volume No. :
5
Issue No. :
3
Year :
2015
ISSN Print :
2231-5667
ISSN Online :
2231-5675
Registration
Allready Registrered
Click to Login
Simultaneous Determination of Carvedilol and Hydrochlorothiazide in Pharmaceutical Dosage Form by Second Order Derivative UV Spectrophotometry
Audumbar Digambar Mali
maliaudu442@gmail.com
Address:
Audumbar Digambar Mali*
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
*Corresponding Author
DOI No:
10.5958/2231-5675.2015.00021.6
ABSTRACT:
Derivative spectrophotometry offers a useful approach for the analysis of drugs in multi-component formulation. In this study a second order derivative spectrophotometric method is applied for the simultaneous determination of Carvedilol and Hydrochlorothiazide in tablet dosage form. The measurements were carried out at wavelengths of 292 and 272 nm for Carvedilol and Hydrochlorothiazide respectively. The method was found to be linear (r²=0.999) in the range of 5-25 µg/ml for Carvedilol in the presence of 20 µg/ml of Hydrochlorothiazide at 292 nm. The linear correlation (r²=0.999) was obtained in the range of 5-25 µg/ml for Hydrochlorothiazide in the presence of 20 µg/ml of Carvedilol at 272 nm. The method was successfully used for simultaneous determination of Carvedilol and Hydrochlorothiazide in tablet dosage form without any interference from excipients and prior separation.
KEYWORDS:
Carvedilol, Hydrochlorothiazide, UV visible spectrophotometry, Method Validation, Accuracy, Pricission, Second order derivative method.
Cite:
Audumbar Digambar Mali. Simultaneous Determination of Carvedilol and Hydrochlorothiazide in Pharmaceutical Dosage Form by Second Order Derivative UV Spectrophotometry. Asian J. Pharm. Ana. 5(3): July- Sept. 2015; Page 133-138.
[View HTML]
[View PDF]
Visitor's No. :
71343