Volume No. :   5

Issue No. :  2

Year :  2015

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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New Spectroscopic Method for Estimation of Atorvastatin Tablets Using Hydrotropic Solubilization Technique



Address:   Dr. N. Usha Rani*, Keerthana. K, Mitha. M, Santhosh Kumar. S, Kotamma. K, Kiran. T.M.N.U.
Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram -535002. AP, India.
*Corresponding Author
DOI No: 10.5958/2231-5675.2015.00016.2

ABSTRACT:
A new, simple, accurate, cost effective and sensitive spectrophotometric method has been developed for the estimation of Atorvastatin (ATV) in tablet dosage form using 0.5 M sodium benzoate aqueous solution as a hydrotropic agent. Aqueous solubility of this model drug was enhanced 22 fold with 0.5M sodium benzoate solution without any interference with the method of analysis. Atorvastatin (ATV) showed maximum absorbance at a wavelength of 268 nm and Beer’s law was obeyed in the concentration range of 0.1-0.6 µg/ml. The method was validated for various parameters according to ICH guidelines. Hence it can be adopted for the routine analysis of Atorvastatin (ATV) in tablet dosage forms.
KEYWORDS:
Atorvastatin, Hydrotropic solubilization, Method development and Validation.
Cite:
N. Usha Rani, Keerthana. K, Mitha. M, Santhosh Kumar. S, Kotamma. K, Kiran. T.M.N.U.. New Spectroscopic Method for Estimation of Atorvastatin Tablets Using Hydrotropic Solubilization Technique. Asian J. Pharm. Ana. 5(2): April-June 2015; Page 100-104.
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