Volume No. :   5

Issue No. :  1

Year :  2015

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Simultaneous Estimation of Irbesartan and Atorvastatin by Q Absorption Ratio Method in their Synthetic Mixture



Address:   Paras Virani1,2*, Rajanit Sojitra2,Bhadresh Savaj2, Hasumati Raj2, Vineet Jain2
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat
*Corresponding Author
DOI No: 10.5958/2231-5675.2015.00002.2

ABSTRACT:
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture using Q absorption Ratio Method. In this spectroscopic method, 234.7 nm (as an iso-absorptive point) and 226 nm wavelengths (?max of any of the two drugs) were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 µg/ml at their respective ?max and at the isoabsorptive point. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.365µg/ml and 0.0622µg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 1.108µg/ml and 0.188µg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 100.51% and 100.16% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.
KEYWORDS:
Irbesartan, atorvastatin, simultaneous estimation, Q absorption ratio method, Q value analysis method.
Cite:
Paras Virani, Rajanit Sojitra,Bhadresh Savaj, Hasumati Raj, Vineet Jain. Simultaneous Estimation of Irbesartan and Atorvastatin by Q Absorption Ratio Method in their Synthetic Mixture. Asian J. Pharm. Ana. 5(1): Jan.- March 2015; Page 9-15.
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