Volume No. :   4

Issue No. :  2

Year :  2014

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method



Address:   Ashok P. Pingale1*, A.R. Rote2, R.B. Saudagar3, Rima R. Patil2, G.B. Jadhav3
1Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, India. Nashik 422002,
2Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai-Agra Road, Panchavati, Nashik.422003, Maharashtra, India.
3KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, India.
*Corresponding Author
DOI No:

ABSTRACT:
Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(? max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5 %±0.95, respectively. Beer’s law for both methods was obeyed in the concentration range 5-25µg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.
KEYWORDS:
Drotaverine HCl, Nimesulide; Absorbance ratio method.
Cite:
Ashok P. Pingale, A.R. Rote, R.B. Saudagar, Rima R. Patil, G.B. Jadhav. Simultaneous Estimation of Drotaverine HCl and Nimesulide in a Tablet Formulation by Absorbance Ratio Method. Asian J. Pharm. Ana. 4(2): April-June 2014; Page 78-81.
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