Volume No. :   3

Issue No. :  4

Year :  2013

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Extractive Spectrophotometric Method for Determination of Aripiprazole Hydrochloride in Bulk and Pharmaceutical Formulations



Address:   Mohan Krishna Lokireddy1*, Jayachandra Reddy. P2, Nallathambi Ramasamy1, Prabhakar Reddy. B1
1Vignan Institute of Pharmaceutical Sciences, Deshmukhi, Nalgonda, Andhra Pradesh, India.
2Krishna Teja Pharmacy College, Tirupati, India
*Corresponding Author
DOI No:

ABSTRACT:
Four simple and sensitive spectrophotometric methods (A – D) for the assay of Aripiprazole in pure and dosage forms based on the formation of chloroform soluble ion-associates under specified experimental conditions are described. Four acidic dyes, namely, wool fast Blue (WFB BL, method A), orange II (Tpooo, method B), Naphthalene Blue 12 BR (NB-12BR, method C), and Azocarmine (AG, method D) are utilized. The extracts of the ion-associates exhibit absorption maxima at 580, 480, 630 and 540 nm for methods A, B, C and D, respectively. Beer’s law and the precision and accuracy of the methods are checked by the UV reference.
KEYWORDS:
Extractive Spectrophotometric Method for Determination of Aripiprazole Hydrochloride in Bulk and Pharmaceutical Formulations
Cite:
Extractive Spectrophotometric Method for Determination of Aripiprazole Hydrochloride in Bulk and Pharmaceutical Formulations. Asian J. Pharm. Ana. 3(4): Oct. - Dec. 2013; Page 127-130.
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