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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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RP-HPLC Analysis for Quantitation of Candesartan Cilexetil in Solid Dosage Forms
Jhansi Lakshmi Marreddy
Revathi R.1*, Saravanan V.S.1, Ethiraj T.2, Jhansi Lakshmi Marreddy1
1Department of Pharmaceutical Analysis, The Erode College of Pharmacy and Research, Erode, Tamil Nadu, India.
2Department of Pharmaceutics, The Erode College of Pharmacy and Research, Erode, Tamil Nadu, India.
A simple reverse phase liquid chromatographic method was developed and validated as per the ICH guidelines for the quantitative determination of candesartan cilexetil in pharmaceutical dosage forms. The mobile phase consisted of 0.02 M mono basic potassium phosphate buffer: acetonitrile: triethyl amine (40:60:0.2) and adjust pH to 6.0 with ortho phosphoric acid. The eluent was monitored at 254 nm, at a flow rate of 2 mL/min and retention time was observed at 9.153 min. The linearity was observed from 0.08071-0.24213 mg/mL with R2= 0.998. The LOD and LOQ were found to be 0.00005 mg/mL and 0.00017 mg/mL respectively. This method was also validated and can be successfully applied for routine analysis.
Candesartan cilexetil, RP-HPLC, Validation.
Revathi R., Saravanan V.S., Ethiraj T., Jhansi Lakshmi Marreddy. RP-HPLC Analysis for Quantitation of Candesartan Cilexetil in Solid Dosage Forms. Asian J. Pharm. Ana. 3(4): Oct. - Dec. 2013; Page 115-118.
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