Volume No. :   3

Issue No. :  4

Year :  2013

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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HPTLC method for routine quality control of Ayurvedic formulation Drakshadi gutika



Address:   V. Jain1*, Tripti Jain2, Swarnlata Saraf1 and S. Saraf1
1University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur (C.G.), 492 010
2Chhattisgarh Food and Drug Administration, Raipur (C.G.) 492 001
*Corresponding Author
DOI No:

ABSTRACT:
The Drakshadi gutika is effective for amlapitta (hyperacidity), hrddaha (heart disease), kanthadaha (itching of throat), trsna (thirst), murccha (syncope), agnimandaya (digestive impairment), bhrama (vertigo) and amavata (rheumatism) is official in Ayurveduc formulary in India. Quantification of active principles through modern analytical tools is essential for establishing the authenticity, creditability, prescription and usage of Ayurvedic medicines/herbal formulations. The Ayurvedic formulation Drakshadi gutika has been prepared as per Ayurvedic formulary of India was estimated HPTLC for its gallic acid content. Three-laboratory batch of Drakshadi gutika were estimated for their gallic acid contents against standard gallic acid solution. The method was validated for linearity, accuracy, limit of detection, limit of quantification, inter-day and intra-day assay precision, repeatability of measurement, and repeatability of sample application. The concentration of gallic acid present in raw material was found to be 8.912±0.41w/w in Terminalia belerica, and 0.73±0.63 w/w in vitis vinifera and in three identical laboratory batch of Drakshadi gutika DG-I, DG-II and DG-III, was found to be 3.307±0.52, 3.301±0.63%, 3.314±0.35 w/w respectively. The gallic acid content in all the three different batches is found to be in close proximities with each other. The results were comparable to marketed formulations. Hence the present method is simple, sensitive, precise and accurate and can be adopted for routine quality control of Drakshadi gutika.
KEYWORDS:
Gallic acid, Drakshadi gutika, HPTLC, Fingerprinting, Ayurvedic formulation, Quality control parameter.
Cite:
V. Jain, Tripti Jain, Swarnlata Saraf, S. Saraf. HPTLC method for routine quality control of Ayurvedic formulation Drakshadi gutika. Asian J. Pharm. Ana. 3(4): Oct. - Dec. 2013; Page 111-114.
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