Volume No. :   2

Issue No. :  3

Year :  2012

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Assay of Lamivudine in Pharmaceutical Preparations by Spectrophotometric Method



Address:   G. Krishnamoorthy*, N. Gayathri, M. Gnanaraja, R. Senthamarai
Department of Pharmaceutical Analysis, Periyar College of Pharmaceutical Sciences, Tiruchirapalli – 620021
*Corresponding Author
DOI No:

ABSTRACT:
A simple spectrophotometric method has been developed for the determination of Lamivudine in bulk and solid dosage form. Lamivudine posses light absorption character in the UV region. The method is based on the measurement of light absorption in the UV region using distilled water. Lamivudine shows maximum absorbance at 271nm.The Beer’s law obeyed in the concentration range of 10-60µg /ml. Results are found satisfactory and reproducible. The proposed method is validated with respect to accuracy, precision, linearity and by recovery studies. The method is applied successfully for the estimation of Lamivudine in tablet dosage form without the interference of excipients. The low value of standard deviation and coefficient of variation indicates that the proposed method is accurate, presise and reproducible
KEYWORDS:
Analysis, absorption maxima, Beer’s range, Lamivudine Tablet, Recovery studies
Cite:
G. Krishnamoorthy, N. Gayathri, M. Gnanaraja, R. Senthamarai. Assay of Lamivudine in Pharmaceutical Preparations by Spectrophotometric Method. Asian J. Pharm. Ana. 2(3): July-Sept. 2012; Page 77-78.
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