Volume No. :   2

Issue No. :  3

Year :  2012

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Second derivative spectrophotometric method for simultaneous determination of tamsulosin and finasteride in pharmaceutical formulations



Address:   Mahesh Nasare, Satish J, A. Manikanta Kumar, V.V.L.N. Prasad, M. Sanayaima Huidrom, Prakash V. Diwan
Department of Pharmaceutical Analysis and Quality Assurance School of Pharmacy, Anurag Group of Institutions. Venkatapur (V), Ghatkesar (M),Rangareddy (D).
*Corresponding Author
DOI No:

ABSTRACT:
Simple and reliable second derivative spectrophotometric method was developed and validated for the simultaneous estimation of tamsulosin and finasteride in bulk and pharmaceutical formulations. The quantitative determination of the drugs was carried out using the second derivative values measured at 239 nm and 232 nm for tamsuloin and finasteride respectively. The solutions of standard and the sample were prepared in methanol. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of 1-8 µg ml-1 for tamsulosin and 12.5-100 µg ml-1 for finasteride. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. Developed second derivative spectrophotometric method was simple, accurate, precise, specific, sensitive and reproducible, which can be directly and easily applied to pharmaceutical dosage forms.
KEYWORDS:
Spectrophotometric method, Second derivative, tamsulosin, finasteride
Cite:
Mahesh Nasare, Satish J, A. Manikanta Kumar, V.V.L.N. Prasad, M. Sanayaima Huidrom, Prakash V. Diwan. Quantitative Evaluation of Carbohydrate Levels in Seeds for Home Use by UV-Visible Spectrophotometer. Asian J. Pharm. Ana. 2(3): July-Sept. 2012; Page 73-76.
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