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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Assay of Ropinirole hydrochloride in Pharmaceutical Preparations by Visible Spectrophotometry
B. Kalyana Ramu
K. Raghubabu1, V. Jagannadharao2, B. Kalyana Ramu3
1Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh (India)
2Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP) India.
3Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
Two simple and sensitive direct visible spectrophotometric methods (M1 and M2) have been developed for the determination of Ropinirole hydrochloride in bulk and solid dosage forms. These methods are based on the reaction of drug with aromatic aldehydes such as Vanillin or Para dimethyl amino Benzaldehyde (PDAB) in the presence of sulphuric acid in non aqueous medium and formed colored condensation products with an absorption maximum of 560nm for method M1 and 660nm for method M2. The Beer’s law obeyed in the concentration range of 5-20µg/ml for method M1 and 25-150µg/ml for method M2. The proposed methods are validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedures are successfully applied to the determination of the drug in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of ropinirole hydrochloride in tablet dosage form without the interference of excipients.
Analysis, Beer’s Law, Condensation reactions, non-ergoline dopamine antagonist, Tablets.
K. Raghubabu, V. Jagannadharao, B. Kalyana Ramu. Assay of Ropinirole hydrochloride in Pharmaceutical Preparations by Visible Spectrophotometry. Asian J. Pharm. Ana. 2(2): April-June 2012; Page 41-45.
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