Volume No. :   2

Issue No. :  1

Year :  2012

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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UV Spectrophotometric Simultaneous Determination of Metformine Hydrochloride and Pioglitazone Hydrochloride in Combined Dosage Form



Address:   Sonali D. Rathod*, P.M. Patil, S. B. Jadhav and P.D. Chaudhari .
Department of Pharmaceutical Chemistry. Modern Collage of Pharmacy, Nigdi, Pune.
*Corresponding Author
DOI No:

ABSTRACT:
Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous quantitation of Metformine Hydrochloride and Pioglitazone Hydrochloride in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In simultaneous equation method, Metformine Hydrochloride and Pioglitazone Hydrochloride were quantified using their absorptivity values of at selected wavelengths, viz., 233 nm and 265.5 nm respectively. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The simultaneous equation method permits simple, rapid and direct determination of Metformine Hydrochloride and Pioglitazone Hydrochloride in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories.
KEYWORDS:
Metformine Hydrochloride and Pioglitazone Hydrochloride, Vierodt’s method.
Cite:
Sonali D. Rathod, P.M. Patil, S. B. Jadhav , P.D. Chaudhari. UV Spectrophotometric Simultaneous Determination of Metformine Hydrochloride and Pioglitazone Hydrochloride in Combined Dosage Form. Asian J. Pharm. Ana. 2(1): Jan.-Mar. 2012; Page 05-09.
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