Volume No. :   1

Issue No. :  4

Year :  2011

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Spectrophotometric Estimation of Rosuvastatin Calcium and Glimepiride in Tablet Dosage Form

Address:   Asma Afroz1, Tasnuva Haque2, Md. Mesbah Uddin Talukder1 and S. M. Ashraful Islam1*
1Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh
2Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka-1217, Bangladesh
*Corresponding Author

In the present study a simple, precise, accurate and reproducible spectrophotometric method has been developed and validated for the quantification of rosuvastatin calcium and glimepiride in solid dosage form by simultaneous equation method. This method uses the spectrum mode of analysis of Simardzu spectrophotometer (UV 1601 and 1240) and utilizes 241 nm and 231 nm as analytical wavelengths for simultaneous estimation. Both the drugs followed Beer’s law in concentration range of 10-22µg/ml. The method was validated in terms of linearity (within 10-22µg/ml), accuracy (% Recovery), precision (inter day and intraday) reproducibility (UV model-1601 and 1240) and robustness. Linearity of the method was with in range and the % recovery was 99.04% for rosuvastatin calcium and 100.94% for glimepiride from the binary mixture. The method was found precise (% RSD< 2%). and robust. Therefore the proposed method is suitable and can be adopted for the simultaneous determination of rosuvastatin calcium and glimepiride from combined pharmaceutical dosage form in routine quality control analysis.
Rosuvastatin calcium, glimepiride, method validation, UV, quantitative analysis.
Asma Afroz, Tasnuva Haque, Md. Mesbah Uddin Talukder, S. M. Ashraful Islam. Spectrophotometric Estimation of Rosuvastatin Calcium and Glimepiride in Tablet Dosage Form. Asian J. Pharm. Ana. 1(4): Oct. - Dec. 2011; Page 74-78.
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