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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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An Analytical Approach of Doxofylline: A Review
Jaydeep S. Yadav
Akhilesh Gupta1*, Vimal Yadav1, Jaydeep S. Yadav1 and Swati Rawat2,
1Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.)
2Shri Bhagwan College of Pharmacy, Aurangabad (M.S.)
Doxofylline is chemically designated as 7-(1, 3 dioxolone-2-yl methyl) theophylline. Presence of a dioxolane group in position C-7 differentiates it from theophylline. It is a new antibronchospastic drug recently introduced in therapy with pharmacological properties like theophylline; a potent adenosine receptor antagonist. doxofylline do not affect gastric acid secretion; either invivo or in-vitro; unlike theophylline. The lack of side effects with doxofylline indicates that the drug can be used safely and effectively. Some analytical methods for quantitative determination of doxofylline in pharmaceutical formulations like UV-Spectrophotometry, HPLC and LC-MS are reported. The present review deals with the various analytical methods reported as well as adopted for the estimation of doxofylline.
Doxofylline, UV, HPLC, LC-MS.
Akhilesh Gupta, Vimal Yadav, Jaydeep S. Yadav, Swati Rawat. An Analytical Approach of Doxofylline: A Review. Asian J. Pharm. Ana. 1(4): Oct. - Dec. 2011; Page 67-70.
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