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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Development and Validation of Spectrophotometric Method for the Estimation of Aripiprazole in Tablet Dosage Form
J. Nagamallika1*, Dr. Aruna Mahesh2
1QIS College of Pharmacy, Vengamukkapalem, Ongole, Andhra Pradesh, India.
2Trinity College of Pharmacy, Peddapally, Karimnagar, Andhra Pradesh, India.
A simple and selective ultraviolet spectroscopic method were developed and validated for the estimation of Aripiprazole in pure form and in their tablet formulations. The adequate drug solubility and maximum assay sensitivity was found in 0.05M Phosphoric acid in water and Acetonitrile in ratio of 40:60 v/v. The absorbance of Aripiprazole was measured at 218nm in the wavelength range of 200 - 400 nm. The linear calibration range was found to be 2.5µg/mL to 20µg/mL. This method was validated and applied to the determination of Aripiprazole in tablets. No interference was found from tablet excipients at the selected wavelength and analysis conditions. It was concluded that the developed methods are accurate, sensitive, precise, and reproducible. They can be applied directly for the estimation of drug content in pharmaceutical formulations.
Aripiprazole, UV Spectrophotometric method.
J. Nagamallika, Aruna Mahesh. Development and Validation of Spectrophotometric Method for the Estimation of Aripiprazole in Tablet Dosage Form. Asian J. Pharm. Ana. 1(3): July-Sept. 2011; Page 46-49.
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