Volume No. :   1

Issue No. :  2

Year :  2011

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form



Address:   Rajendran S.S.*, Santhi N., Kumar Nallasivan P., Sam Solomon W.D., Venkata Narayanan R.
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore
*Corresponding Author
DOI No:

ABSTRACT:
Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (?max of Cefixime) and 297.4nm (?max of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (?max of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5-25 µg/ml for Cefixime and 2-10 µg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.
KEYWORDS:
Cefixime; Ofloxacin; Simultaneous equations; Absorbance ratio method.
Cite:
Rajendran S.S., Santhi N., Kumar Nallasivan P., Sam Solomon W.D., Venkata Narayanan R.. Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form. Asian J. Pharm. Ana. 1(2): April-June 2011; Page 36-38.
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