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Asian Journal of Pharmaceutical Analysis
ISSN: 2231-5675(Online), 2231-5667(Print)
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Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form
Kumar Nallasivan P.
Sam Solomon W.D.
Venkata Narayanan R.
Rajendran S.S.*, Santhi N., Kumar Nallasivan P., Sam Solomon W.D., Venkata Narayanan R.
RVS College of Pharmaceutical Sciences, Sulur, Coimbatore
Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (?max of Cefixime) and 297.4nm (?max of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (?max of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5-25 µg/ml for Cefixime and 2-10 µg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.
Cefixime; Ofloxacin; Simultaneous equations; Absorbance ratio method.
Rajendran S.S., Santhi N., Kumar Nallasivan P., Sam Solomon W.D., Venkata Narayanan R.. Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form. Asian J. Pharm. Ana. 1(2): April-June 2011; Page 36-38.
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