Volume No. :   1

Issue No. :  1

Year :  2011

ISSN Print :  2231-5667

ISSN Online :  2231-5675


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Stability Indicating Liquid Chromatographic Method for Aripiprazole



Address:   G. Raveendra Babu1*, J. Srinivasa Rao2, K. Suresh kumar2 and P. Jayachandra Reddy3
1Dr.Reddy’s Laboratories Ltd, Bachupally, Hyderabad, Andhra Pradesh, India.
2United States Pharmacopeia-India Pvt. Ltd, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, India
3Krishna Teja Pharmacy College, Tirupathi, Chittor (Dt), Andhra Pradesh, India.
*Corresponding Author
DOI No:

ABSTRACT:
A novel stability indicating liquid chromatographic assay method was developed and validated as per ICH guide lines for the quantitative estimation of Aripiprazole in tablet formulation. An isocratic reverse phase LC-method was developed using Phenomenex Luna C18, 150 x 4.6mm, 5µm column and a mobile phase comprising of Acetonitrile and Phosphate buffer, 0.05M (40:60 v/v). The detector set at 227nm with flow rate of 1.0mL min-1.The method is Linear in rage of 25µg mL-1 to 200 µg mL-1. The Accuracy of the method was found to be in the range of 99.95% to 100.0%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 1.0%. The Analyte and mobile phase were stable up to 48hours. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Aripiprazole in tablet formulations and can be used for commercial purposes.
KEYWORDS:
Aripiprazole, Liquid Chromatography, Stress degradation and Method validation..
Cite:
G. Raveendra Babu, J. Srinivasa Rao, K. Suresh kumar, P. Jayachandra Reddy. Stability Indicating Liquid Chromatographic Method for Aripiprazole. Asian J. Pharm. Ana. 1(1): Jan.-Mar. 2011; Page 03-07.
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